I don't think guys and girls can be best friends. Just regular friends, yes. In most cases the guy really cares for the girl. But it's too late because the girl already friend zoned him. Or even worse best friend zoned him. Most people at it's the girl that wants to be with the guy. But from what I've seen, its always the guy that develops the feelings first. Almost every best friendships I've seen between guys and girls, **** up in one getting extremely jealous, or they get together. A few people I know, Rey ***** up getting drunk and having *** with their best friend. And waking up the next morning in he'd with eachother, and that was the start to their relationship.